Michael C Frühwald Selected Research

Rhabdoid Tumor (Rhabdoid Tumors)

12/2021	Clinical evidence for a biological effect of epigenetically active decitabine in relapsed or progressive rhabdoid tumors.
1/2021	Inhibition of nuclear export restores nuclear localization and residual tumor suppressor function of truncated SMARCB1/INI1 protein in a molecular subset of atypical teratoid/rhabdoid tumors.
1/2021	Transposable element insertion as a mechanism of SMARCB1 inactivation in atypical teratoid/rhabdoid tumor.
11/2019	Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration.
1/2018	Emerging therapeutic targets for the treatment of malignant rhabdoid tumors.
1/2018	KBG syndrome patient due to 16q24.3 microdeletion presenting with a paratesticular rhabdoid tumor: Coincidence or cancer predisposition?
1/2018	Sellar Region Atypical Teratoid/Rhabdoid Tumors (ATRT) in Adults Display DNA Methylation Profiles of the ATRT-MYC Subgroup.
11/2017	Reduced histone H3 K27 trimethylation is encountered in about 50% of atypical teratoid/rhabdoid tumors (AT/RT) but is not associated with molecular subgroup status and outcome.
7/2017	BRD9 Inhibition, Alone or in Combination with Cytostatic Compounds as a Therapeutic Approach in Rhabdoid Tumors.
1/2017	SMAD dependent signaling plays a detrimental role in a fly model of SMARCB1-deficiency and the biology of atypical teratoid/rhabdoid tumors.

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Michael C Frühwald Research Topics

Disease

44	Neoplasms (Cancer) 04/2022 - 01/2002
24	Rhabdoid Tumor (Rhabdoid Tumors) 12/2021 - 04/2007
6	Typical Teratoid Rhabdoid Tumor 01/2022 - 06/2011
5	Ependymoma 01/2021 - 05/2004
5	Glioblastoma (Glioblastoma Multiforme) 01/2017 - 05/2004
5	Medulloblastoma 01/2014 - 05/2004
4	Glioma (Gliomas) 01/2022 - 01/2009
4	Primitive Neuroectodermal Tumors (PNET) 02/2016 - 05/2004
3	Neoplasm Metastasis (Metastasis) 01/2022 - 09/2014
3	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2019 - 06/2010
3	Neuroblastoma 02/2017 - 04/2007
3	Ewing Sarcoma (Sarcoma, Ewing) 09/2015 - 10/2012
3	Pathologic Complete Response 09/2014 - 12/2009
2	Brain Neoplasms (Brain Tumor) 01/2019 - 06/2011
2	Neuroectodermal Tumors (Neuroectodermal Tumor) 08/2013 - 12/2009
2	Osteosarcoma (Osteogenic Sarcoma) 01/2013 - 10/2012
1	Li-Fraumeni Syndrome 01/2022
1	Central Nervous System Neoplasms 01/2022
1	Thyroid Neoplasms (Thyroid Cancer) 01/2022
1	Prostatic Neoplasms (Prostate Cancer) 12/2021
1	Hematologic Neoplasms (Hematological Malignancy) 12/2021
1	Residual Neoplasm 01/2021
1	Rhabdoid Tumor Predisposition Syndrome 1 01/2021
1	Carcinogenesis 01/2020
1	Cardiotoxicity 01/2020
1	Leukemia 12/2019
1	Lymphoma (Lymphomas) 12/2019
1	Diffuse Intrinsic Pontine Glioma 01/2019
1	Thrombocytopenia (Thrombopenia) 10/2018
1	Nicolaides Baraitser syndrome 01/2018
1	Pituitary Neoplasms (Pituitary Adenoma) 01/2018
1	KBG syndrome 01/2018
1	Coffin-Siris syndrome 01/2018
1	Sarcoma (Soft Tissue Sarcoma) 05/2017
1	Spontaneous Remission 02/2017
1	Cytopenia 03/2016
1	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 03/2016
1	Infratentorial Neoplasms (Posterior Fossa Tumors) 01/2016

Drug/Important Bio-Agent (IBA)

12	Proteins (Proteins, Gene)FDA Link 01/2022 - 12/2009
5	Biological ProductsIBA 12/2021 - 11/2009
5	Temozolomide (Temodar)FDA LinkGeneric 01/2021 - 01/2009
4	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 01/2002
4	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2020 - 06/2010
3	NucleotidesIBA 01/2021 - 01/2018
3	Sucrose (Saccharose)IBA 01/2020 - 09/2014
3	Vorinostat FDA Link 12/2019 - 04/2007
3	Histone Deacetylase InhibitorsIBA 12/2019 - 04/2007
3	ChromatinIBA 01/2019 - 01/2012
3	Histones (Histone)IBA 11/2017 - 01/2003
3	hydrogen sulfite (bisulfite)IBA 03/2016 - 01/2009
3	Etoposide (VP 16)FDA LinkGeneric 09/2015 - 09/2007
2	Decitabine FDA Link 01/2022 - 12/2021
2	SMARCB1 ProteinIBA 01/2021 - 09/2014
2	Asparaginase (Elspar)FDA Link 01/2019 - 06/2010
2	Cyclin D1IBA 01/2018 - 06/2010
2	Vincristine (Oncovin)FDA LinkGeneric 05/2015 - 09/2014
2	Cyclophosphamide (Cytoxan)FDA LinkGeneric 05/2015 - 09/2007
2	Antineoplastic Agents (Antineoplastics)IBA 03/2015 - 06/2010
2	Dactinomycin (Actinomycin)FDA LinkGeneric 09/2014 - 06/2010
2	AnthracyclinesIBA 09/2014 - 06/2010
2	Somatostatin Receptors (Somatostatin Receptor)IBA 08/2013 - 05/2004
2	Adenosine Triphosphatases (ATPase)IBA 06/2011 - 02/2010
2	Nonsense Codon (Nonsense Mutation)IBA 06/2011 - 02/2010
2	Methotrexate (Mexate)FDA LinkGeneric 08/2010 - 06/2010
1	CPS 49IBA 04/2022
1	Capsules (Microcapsules)IBA 01/2022
1	Thyroglobulin FDA Link 01/2022
1	ProteomeIBA 12/2021
1	Biomarkers (Surrogate Marker)IBA 01/2021
1	selinexorIBA 01/2021
1	Hematoxylin (Haematoxylon)IBA 01/2021
1	DNA Transposable Elements (Element, IS)IBA 01/2021
1	Eosine Yellowish-(YS) (Eosin)IBA 01/2021
1	AntigensIBA 01/2020
1	Calcitonin (Calcitonin, Eel)FDA LinkGeneric 01/2020
1	pegaspargase (Oncaspar)FDA Link 01/2019
1	dipinacoline glutamateIBA 01/2019
1	AsparagineIBA 01/2019
1	Microfilament Proteins (Actin Binding Proteins)IBA 10/2018
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2018
1	CateninsIBA 01/2018
1	LigandsIBA 01/2018
1	Aurora Kinase AIBA 01/2018
1	dimemorfan (AT 17)IBA 01/2018
1	Cytostatic AgentsIBA 07/2017
1	Transforming Growth Factor beta (TGF-beta)IBA 01/2017
1	Bevacizumab (Avastin)FDA Link 01/2017
1	Small Interfering RNA (siRNA)IBA 01/2017
1	Azacitidine (5 Azacytidine)FDA Link 03/2016
1	VaccinesIBA 01/2016

Therapy/Procedure

21	Therapeutics 01/2022 - 12/2009
8	Drug Therapy (Chemotherapy) 01/2021 - 01/2009
3	Immunotherapy 11/2019 - 01/2016
3	Ligation 01/2018 - 09/2014
2	Investigational Therapies (Experimental Therapy) 10/2021 - 10/2013
2	Radiotherapy 01/2020 - 05/2017
2	Precision Medicine 01/2019 - 01/2016
1	Thyroidectomy 01/2022
1	Liver Transplantation 02/2017
1	Drug Tapering 03/2016